If you have a look at the main map of any act (U by default), you can notice that areas are oriented. For instance, in the first act's main map, Tidal Island is south of Terraces. And indeed, I've always found Terraces at the far south of the Tidal Island area.
Is there some kind of constraint on the orientation of the points of interest during the generation of an area ? Is it possible to use it to buy some time while looking for something specific in an area (a waypoint, for example) ?