Fallen Enchantress is a 4X game with magic. You start with one guy who founds a city, and try to crush the world under your iron heel (for their own good, of course).
As far as I can tell, there's no drawback to building additional cities, aside from "I could have been doing something else." Making more cities means more construction points, more research, more gold, more resources, and less territory available to your opponents. The world is scattered with wild monsters and neutral factions, but they mostly ignore cities. Is there any reason not to go wild and build as many cities as possible as soon as possible, while mostly ignoring your infrastructure and military until you run out of places to settle?
I ask because the game's tutorials are extremely basic, and I can't tell if there's some mechanism that makes city-spam unproductive (such as how Civilization IV had a "tax" on expansion, and Civilization V used Global Happiness to limit growth). The game limits spacing of cities (legal places to put a city are somewhat few and far between), but doesn't seem to have any limits on how quickly you can found new cities.