I'm currently running through OWB and noticed something rather annoying. When I'm using V.A.T.S. at point blank range, I seem to almost always miss. When the camera zooms out to run the animation and the mob is chewing on my neck, my gun is actually firing past the hit box of the mob. It almost seems like the game takes this into account and registers my bullets actually firing past the mob and not at it. This is especially clear when fighting fast mobs like nightstalkers since they some times get the jump on me. I've never gotten this from cazadors and I think it's because they fly and "get in the way" of my gun, whereas a ground based mob like a nightstalker gets out of gunpoint because it's below my line of sight, and the animation shows me firing straight forward.
I've only encountered this in V.A.T.S. and only when my own and the mob's hitboxes are nearly merged together. Anyone else experienced this?