I know that slot machines are generally a sucker's game, but they also have the highest potential payouts. That said, after fighting one at the Atomic Wrangler for the better part of an hour, I'm not even near breaking even, and the best spins I've seen have been two cherries.
Is there a list of the odds of each reward? Does it vary by casino? Also, has anyone ever actually seen a decent payout on the New Vegas slots without having a 10 Luck stat?