I've installed Skyrim on my Intel 4000 CPU/CPU based Ubuntu system via PlayOnLinux (latest as of today, tried with wine ~1.5 and ~1.6 rc 1).
When I load Skyrim, the mouse cursor shows for maybe 1/4 a second. When the pixilated smoke under the dragon starts, the mouse pointer disappears. When I move the mouse, I can see it highlight "Continue" and other menu choices.
Messing with the .ini I've tried:
bGamepadEnable=0 fHUDOpacity=0 bGamePadRumble=0 bMouseAcceleration=0 iPresentInterval=0
...turning the numlock off, overridding input and input8 in winepreferences, switched through all graphics settings for DirectDraw renderer, Offscreen Rendering mode, Multisampling, Strict Draw ordering.
Very grateful for any ideas or suggestions.