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I have the quest "ED-E My Love". However, I cannot just pick him up and walk outside (he's in a house). Is it possible to do that quest when I don't have the science/repair to fix him first?

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up vote 7 down vote accepted

No. You'll need to get Ed-E fixed up first. If you lack the requisite Science or Repair skills, you should be able to substitute a lot of parts for any actual knowledge. Specifically, 3 Scrap Metal, 2 Sensor Modules, and one Scrap Electronics.

Alternately, you can just come back later, or pop a Skill Magazine.

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The materials to fix ED-E are over at the lone wolf radio location west of the road from goodsprings to primm... – chris.w.mclean Jan 5 '11 at 17:24

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