In Skyrim there are a few drugs and alcoholic beverages and I couldn't really figure out whether or not there are big disadvantages. I always rely on my own potions because I'm not sure about the side effects of those things.
Can you get addicted by certain drugs (let's say Skooma) or can the game be unplayable due to a blurry screen? Or does it even reduce skill levels and/or other important things at some points? What are the advantages/disadvantages of drinking alcohol and taking drugs in Skyrim?