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Does the order in which I do the missions in GTA IV matter? And more specifically, is it possible that a mission will become no longer available just because of another mission I perform before it?

Right now I'm assuming there's no problem and whenever I am free I just go to the nearest available mission, but I was started to get worried that it might cause me to miss out on missions.

Clarification: by "missions" I only mean the missions you receive from going to the map locations marked with letters, not activities such as stealing cars for Brucie or vigilante missions.

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up vote 5 down vote accepted

From my experience playing the whole GTA series where the game is based around free-roaming. You can go do all the side missions and return to a storyline mission without any disadvantages.

In the context of GTA IV, I would say that the only benefit to doing the missions in an orderly fashion is you gain better weapons/services/money to assist you when the harder missions further on in the game are available.

Overall, the sub missions wont affect your main storyline missions, and vice-versa.

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Actually, I can't really tell which missions are side missions and which are storyline missions. And I can't really tell how to do them in an orderly fashion, either... – Oak Apr 25 '11 at 15:21
@Oak what I mean by side missions is the ambulance driver missions or the fire brigade missions, or the Brucie vehicle missons. Things that dont impact directly with the storyline but go towards your 100% completions. With GTA IV I found doing a misson was simply based on whether I wanted to know about the story going on. – House Apr 25 '11 at 16:12
Oh right, I didn't mean those at all; I've clarified my question to exclude those. – Oak Apr 25 '11 at 16:16

Typically from when I played through GTA 4 most of the missions would go in an order that would fit with the story. Say you have 3 places to go to, they would all fit with the story at that point. It seemed like you would go and do all of the missions and then the story would advance once everything was finished.

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