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Dead Eye gives an increasing damage multiplier based on how many consecutive hits you've landed. In a recent run I collected it along with 20/20 and Inner Eye, giving me 6 tears per shot total. I watched my shots carefully, but my damage modifier seemed to be resetting unpredictably.

What counts as a hit or a miss in this scenario? Is there a certain threshold for how many tears out of a single shot have to hit an enemy?

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I don't have enough for a full answer at this time, but ever tear you fire has the potential to be a miss, so Loki's Horns or Mom's Eye work against with Dead Eye. Also, piercing effects seem to disable Dead Eye completely ATM, causing ever tear to count as a miss – Dallium Nov 3 '15 at 6:53
    
@Dallium Thanks for that note - that would explain why I never saw it stacking again after picking up Death's Touch. – Chris Hayes Nov 4 '15 at 1:27
up vote 2 down vote accepted

I think that shooting 6 tears simultaneously is the problem, because if one of the front tears kills the enemy the other(s) will miss and reset your multiplier.

UPDATE:

In a recent update though, it was modified so that multi-shot effects only require one of the tears to hit an enemy, and piercing effects do not interrupt it either.

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Afterbirth added a number of new synergies for power combinations, the Wiki might be lagging behind in some areas; the link for 20/20 states "DLC The Inner Eye: 6 shots are fired with normal tears decrease." – Trent Hawkins Nov 3 '15 at 15:05
    
@TrentHawkins Oh you are right, I've read only what's written in the section "Interaction". – pinckerman Nov 3 '15 at 15:08
    
I suspect you're right but I'd really like some confirmation rather than theory. I'm going to try to get this scenario again and run through it. – Chris Hayes Nov 6 '15 at 2:22
    
@ChrisHayes Sure. I hope you remember the seed of that run. – pinckerman Nov 6 '15 at 2:47
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It's actually pretty liberal with multi-shot effects, to the point where I was using Tear Detonator and still keeping the streak as long as one of the detonated tears hit an enemy. It's much easier to avoid breaking your synergy now. – Chris Hayes Dec 17 '15 at 5:31

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