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The question What is the benefit of using V.A.T.S.? is about the advantages of using the V.A.T.S system.

Are there any disadvantages, other than it being limited by APs? In Fallout 3, weapons broke down faster by using it, but obviously that's not the case in part 4 as weapons don't degrade.

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up vote 17 down vote accepted

Aside from AP limitations, there is also the fact that VATS drains Fusion Cores more quickly, as mentioned by @HopelessN00b. Also keep in mind that aiming manually may have tactical advantages over VATS depending on circumstances.

Those circumstances include:

  • Enemies that are behind heavy cover may have a 95% chance of getting hit in VATS, but your VATS shot will always hit the cover instead.
  • Enemies may hide behind cover while you're still shooting using VATS, in which case you'll have to cancel VATS to stop wasting your AP.
  • VATS loses a lot of accuracy over long distances, even if you have a sniper rifle equipped and your enemy is hardly moving.
  • VATS does not allow you to move. If you need to dodge while attacking, VATS is not for you.
  • You are vulnerable while targeting. VATS does not stop time, it only slows it. While you're deciding which enemy or body part to hit, you remain cannon fodder for others. Fortunately, as you receive 90% damage resistance while in VATS, this point is not as bad as it might seem.
  • VATS is generally a bad fit with heavy weaponry. Rockets/Nukes may be launched even when the enemy has gotten too close. Miniguns will be shot in salvos which will either all hit a single target, or all miss (very bad if you're being overrun and don't care about hitting a single target).
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VATS uses AP, which drains your fusion core while in power armor. One of your points mentions being "cannon fodder", but it might be good to point out that you have 90% damage resistance while in VATS. – DCShannon Mar 15 at 20:09
    
@DCShannon. Thanks, updated my answer. – Nolonar Mar 15 at 20:12
    
The final point is not necessarily the case. You can fire a MIRV Big Boy at point blank range at an enemy from within VATS, and the resultant explosion will OHKO the enemy, but only deal minimal splash damage to you due to the 90(95?)% DR. – March Ho Apr 21 at 6:32

In addition to the the points brought up in Nolanar's answer, VATS burns through fusion cells very quickly, which is a serious drawback for power armor users.

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