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In my computer I have both a Sound Blaster Live! 5.1 SB0220 card and a Realtek ALC850 chipset on an MSI K9N4 nForce 500 motherboard. My game crashes on launch, just after the Bethesda logo fades. I've tried both cards with multiple drivers, with the same results.
I've seen the workaround which involves changing the audio sample rate to 16bit 44100Hz, but to the best of my knowledge, both cards seem to only support a 16bit 48000Hz sample rate. Are there any other workarounds, or does Skyrim simply not support my hardware?