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The item description is very vague, simply stating what it does without any specifics. I'd rather not spend 200 rupees on it if it only provides a slight reduction for less than a minute.

How much damage reduction does it provide, and how long does it last?

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And be sure to carry the Potion Medal (Skipper's Retreat Goddess Cube) so the effect of your buffs last twice as long - or 3 times in fact, I'm not sure - that might be only in the Boss Battle mode. – HSO Jan 3 '12 at 11:36
up vote 9 down vote accepted

It just reduces the amount of damage you take by half. It lasts for 3 minutes.

I would infuse it instead of using it as is. When infused as Guardian Potion+, you are invulnerable for 3 minutes instead.

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