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I currently have no runes on LoL, and I want to start building mainly for dps..
I used the rune mixer but is seems expensive!

Any hints?

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Sorry for nitpicking, but you may want to perform a slight touch-up on your question's title: "thew chaepest" => "the cheapest" –  Aubergine Aug 15 '10 at 8:48
    
+1 tnxs dude. . . –  Fabiano PS Aug 16 '10 at 20:45
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4 Answers

up vote 1 down vote accepted

A few suggestions I can give are:

Mostly DPS

  1. Armor Pen Marks - Desolation
    • (very effective early game and useful against most teams. Crits don't give as much if you're not playing Tryn or possibly Gangplank)
  2. Magic Resist Glyphs - Warding
    • (every hero has just about at least one spell that will hurt you)
  3. or CD reduction Glyphs - Celerity or Focus
    • (always nice to have. Personally I've never felt the need to stack up on mana. There are a lot of masteries for that and unless you're going for a heavy healer like Taric or Soraka or siege heavy Heimer you'll most likely get to farm at least an item for mana. Also ninjas and some dps heroes don't need this which makes this a total waste if you're saving IP)
  4. Evasion Seals - Evasion
    • (Evasion helps a lot of heroes, there's only one counter to this and that's SoD which seems like a stable item only for TF. Also stacks additively which means that for heroes like Sivir or Jax you'd have a pretty high chance of attacks missing you)

With Quints you can just about pick anything except those that just give mana or hp/mana regen. I'd suggest you just pick out what defines your playstyle most.

Personally, I wish I'd known about these sooner because I invested in a lot of Crit Runes, Armor Runes and Magic Resist. XD They're pretty fun when last hitting creeps early game or getting a crit on one normal attack but really just flimsy at best unless you play a lot of Tryn or Gang. Now I can't buy new runes because Riot keeps pumping all these awesome heroes every 2 weeks and I get only 200 ip a day on average.

And only, only use the combiner when you have some leftover tier 2 runes that you want to move a tier up.

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I use APen or MPen on 90% of rune builds and armour / mres on about 50%. –  theorise Mar 10 '11 at 15:36
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My recommendations:

Glyphs

  • Celerity Cooldown Reduction/lvl (410)
  • Shielding Magic Resist/lvl (205)
  • Potency Ability Power (410)


Seals

  • Clarity Mana regen/lvl (205)
  • Replenishment Mana regen (205)
  • Resilience Armor (205)
  • Vitality Health/lvl (410)


Marks

  • Desolation Armor Pen (410)
  • Insight Magic Pen (410)
  • Strength Attack Dmg (205)

Quintessences

  • Any of the above
  • Fortitude. 26 Health (2050). Expensive, but good on ALL champions.


You can get more specific info form this List of Runes. Note that evasion/dodge, which is mentioned in other answers, has been completely removed from the game.

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if you go mainly for physical dps then i would suggest to invest into armor penetration for the red runes, evasion for yellow, manaregen for blue and strength for the big ones.

reason: you dont want to buy armor penetration and manaregen on a dps hero, yet you need both at some point in the game. armor penetration gives you more dps and manaregen is good to have in an early game.

The runes work out for most phys champions without losing effectivity, so you dont need several runesets. for a mage ofc you would need much different runes, also if you went a mage route with your champion, because they buy different items. for a tristana/yi the blue runes suffice for mana management, but for a ryze you would need more and thus would have to buy the item, making the runes useless.

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I used to do the rune mixer route, but I found it to be too random for my tastes. Instead I decided to look up some guides for champions that I enjoyed playing, and then buy runes based on those guides.

Check out mobafire.com for champion guides, and then build rune pages based on the guides :)

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Also leaguecraft.com. It's a good place to look for guides too. –  Jonn Sep 2 '10 at 12:40
    
The best use for the rune combinator is to combine any Tier 1/2 runes up to Tier 3. –  Toast Feb 22 '12 at 21:05
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