Most PS3 game save I tried aren't compatible with different regional versions of the same game, but does Mass Effect 3 allow you to import a Mass Effect 2 save from a different region? For example, if I played Mass Effect 2 off a US disc (Region 1) and start Mass Effect 3 with a UK disc (Region 2), will my old save work?
This works with only save files that can be copied if you have a stock PS3 firmware.
If you are using custom firmware, you can use a file manager or multiman to copy the GAMEDATA folder to a usb stick and use PS3Tools from aldsotools to hack the save file's region.
PS3 games are region free but the game saves are apparently not. I haven't used any cross-region games on my PS3, so I haven't experienced the particulars.
Someone does suggest a (fairly complex) method of getting around PS3 save region lock though:
This should work for any PS3 game, ME3 included if ME3 is indeed region locked; and since it's EA, I would go ahead and assume they did as much locking and DRM as feasible.