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Depending on choices from ME1, ME2, ME3, is it possible to have only two remaining squad members to select from for the final ME3 mission?

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I'm fairly certain it's not. I'm pretty sure only Ashley, Kaiden, Tali and Garrus can die. I'm pretty sure it's impossible for Javik, EDI, Liara or James to die. – Mr Smooth Mar 15 '12 at 17:05
I'm pretty sure everyone wants to kill James though... – Brandon Mar 15 '12 at 17:25
@Brandon: Link for effect. – MBraedley Mar 15 '12 at 17:47
up vote 2 down vote accepted

I don't believe this is possible, even without DLC. Hidden for possible spoilers:

You can avoid adding the Virmire survivor to your party, and it's possible for Garrus and Tali to die in ME2 (and Tali can die in ME3 as well), but I don't think there is any way to get rid of Liara, James, and EDI. You should always have at least those three.

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Ah, I forget about the synthetic when thinking about this in my head. – Elpezmuerto Mar 15 '12 at 18:02

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