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This is a pretty simple one. Are there any missions in the game that are mutually exclusive? That is, are there any two or more missions that are uncompletable in a single playthrough?

For example, say the missions Kill Guys #5, Fetch Quest #11, and Planet Scanner #19 are available to complete. When I finish mission Fetch Quest #11, mission Kill Guys #5 becomes unavailable. However, at the same time, if I finish Kill Guys #5, mission Fetch Quest #11 becomes unavailable. Therefore, it's impossible to complete Kill Guys #5 and Fetch Quest #11 in a single playthrough due to the missions canceling each other out.

Are there any actual scenarios like the example above in the game?

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There have never been missions in mass effect which are mutually exclusieve. –  Rare Candy Mar 20 '12 at 22:46

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up vote 5 down vote accepted

Nope. As long as you complete the timed missions and other side missions before Priority missions, you won't miss any.

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any proof? -1 till you do. –  Paralytic Mar 20 '12 at 7:36
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+1 because @Paralytic is asking for the impossible. –  kotekzot Mar 20 '12 at 9:27
    
not really he doesnt even say if he has completed the game or anything just says no. –  Paralytic Mar 20 '12 at 9:30
    
@Paralytic: The only mission I didn't complete was the side mission on Eden Prime, and that's only because it becomes locked out after leaving with Javik. Is it possible that I didn't acquire every mission on the Citadel? Sure, but in previous games you didn't receive missions that were mutually exclusive, and I haven't seen evidence for that in ME3. –  MBraedley Mar 20 '12 at 11:09
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@Para That's an interesting point. The in-game Journal is absolutely no help at telling you if you've done everything. –  Ampersand Mar 20 '12 at 16:25

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