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I was wondering if Pix's 3 hits count for things like Ionic Spark or proc the effects of Wit's End. If nothing else, does Spell Vamp proc off of their dmg?

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No, they don't apply on-hit effects or procs. Nor does it give spell vamp. It is just a little extra damage, and that's all. I have played her AP, I know first hand with spell vamp and rylias (on hit effect).

Edit: this is backed up by the LoL Wikia as well: [1]

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People are much more likely to upvote you if you back up your answer with sources. – Rapida Mar 26 '12 at 0:15
Well I play her, so I know first hand. NBD though. – Agilism Mar 26 '12 at 0:18
@Agilism What rapida means is that if you provide your reasoning why you think / know this, users are more likely to up vote / believe your answer. So editing your post to include that you know this since you play her would count as "including sources". – Wipqozn Mar 26 '12 at 0:20
Yes, it makes sense. I'm not arguing the point. Facts need proof to be facts. – Agilism Mar 26 '12 at 0:25
I added the wikia link that state non effect of on hit effect and spell vamp effect. – M'vy May 18 '12 at 9:26

No, they don't. Pix is counted as a separate unit, which is why you can attach it to other people.

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