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I just found a heart! Unfortunately, I don't need this heart, but I am 100% sure I will need it later. If I leave the heart alone long enough, will it disappear? What about coins and other items?

enter image description here

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I will point out that in that picture, you have no choice but to leave the hearts. You can't pick up hearts if you are at full health. – murgatroid99 Mar 30 '12 at 17:00
@murgatroid99 - I know that's why I asked :P – user9983 Mar 30 '12 at 17:03
up vote 8 down vote accepted

No, items on the ground never despawn as long as you are on the same floor (and once you leave it doesn't matter since you can never come back anyway).

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As added note, you even see the items left behind on the minimap. Though, only one per room, I think. – DJ Pirtu Mar 30 '12 at 18:43
Yeah, that's pretty helpful – murgatroid99 Mar 30 '12 at 18:45

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