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For some reason, no matter what button I press on the difficulty screen on Dungeons of Dredmor, it automatically selects Dwarvish Moderation and Permadeath. Doesn't matter where I click, or whether I press up or down, etc. Hell, I can hit the back button and it moves to the Skill Select screen. Has anybody else had this problem, and how do I solve it?

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Thanks! The mouse-over/mouse-wheel technique works really well. – azof02 Apr 17 '12 at 20:09
Cool, glad it helped. I turned it into an actual answer below. I'd hesitated making it a "real" answer initially because I had no way to verify it. – Sterno Apr 17 '12 at 20:12

This appears to be a problem that many users have had since the game's release, and there has not yet been an official fix.

Here's one possible solution you might try.

After some experimentation, I resolved the issue by floating my cursor over the settings and scrolling with the mousewheel to select or deselect options

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