I'm still at the start of the game but one thing is annoying as hell: whenever I'm maneuvering around in the map and the game needs to load something (e.g. a sound or such a thing), there's a stutter or a short pause so to say.
E.g. I climb up something it's clear that the game suddenly pauses for the sound load (at least that's my impression) the first thing it needs to play it. I've also saw this the first time the wolf came at me right in the tutorial: a short stop and then the sound played.
What's also really annoying about this is that it almost always breaks the tension because I already can expect something to happen the next moment.
I'm on a W7Pro 64 with 12GB RAM, i980EE@3.3Ghz with Intel 160GB SSD and a HD 5970 so I hardly think it's the spec not being enough and thus all my searching with Google and friends turning nothing up (they usually expect hardware not sufficient problems).
I also notice some weird stop, albeit less annoying, when calling up the Objective or Log screens (I expect the game to pause in this case, so no problem).