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At the end of Diablo 2

Tyrael destroys the Worldstone to prevent its corruption.

Has there been any official word about the consequences of that action? Or the lives of the people of Sanctuary has not been affected by it?

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up vote 4 down vote accepted

The first inhabitants of Sanctuary were super-humans called the Nephalem. They were the children of an Angel (Inarius) and a Demon (Lilith). The Nephalem were so powerful that their existence sparked the Sin War between the angels and demons. Other subplots aside, Inarius became jealous of the power of the Nephalem and created the Worldstone to contain their power.

Inarius used the worldstone to prevent the Nephalem from developing their powers, reducing each succeeding generation's power until they became normal humans of Sanctuary.

Given that, with the Worldstone destroyed - humankind may grow to significant power again and spark a new Sin War.

As you can see in the Nephalem article on the wiki, the Nephalem play a role in the quests of Diablo III. It is hard to predict the full effects with the game not yet released, but based on the lore the destruction of the Worldstone should at least make humankind significantly more powerful.

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to quote the diablo wiki, it seems like nobody knows for sure but we might see that in diabo 3:

The full effects of destroying the Worldstone are yet to be revealed. Many speculate that Tyrael has somehow been corrupted by Baal or the corrupted Worldstone. All should be revealed in Diablo III. Even the characters in Diablo II aren't sure of what will happen now that it is destroyed, or even if it had to be destroyed in the first place. The Prophecy stated that the Worldstone would be corrupted, but apparently never actually said anything about it having to be destroyed.

maybe some beta-testers of diablo 3 (more than the open beta with level-13-limit) could give more information - but i'm almost sure this would be against the terms of use of the beta, so thats unlikely to happen.

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Since there's no NDA on the Diablo 3 beta since last year's July, that shouldn't be a problem. – Kappei May 2 '12 at 8:29
Thanks for the info - but anyway, it's just 13 days left until diablo 3 is released and we all can find out on our own. – oezi May 2 '12 at 8:32
The beta didn't give any more details on this. – bwarner May 2 '12 at 11:51

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