Here's a potential DPS-focused build: http://us.battle.net/d3/en/calculator/monk#WbXYek!gfX!acbcaa.
Left-Click: Crippling Wave, Mangle Rune (143% weapon damage)
Right-Click: Deadly Reach, Foresight Rune (increases damage by 18% for 30s)
Slot 1: Breath of Heaven, Blazing Wrath Rune (increases damage by 15% for 45s)
Slot 2: Blinding Flash, Faith in the Light Rune (increases damage by 30% for 3s)
Slot 3: Wave of Light, Wall of Light Rune (312% strike damage)
Slot 4: Mantra of Conviction, Overawe Rune (doubles aura strength to 24%/48%)
Passive 1: Combination Strike
Passive 2: Guiding Light
Passive 3: Seize the Initiative
Damage buffs from different skills apply multiplicatively, whereas damage buffs from the same skill apply additively. For example, DR/Foresight and BoH/Blazing Wrath combine for 1.18 * 1.15 = 1.36, or a 36% damage increase (better than 15% + 18% = 33%!). In contrast, Combination Strike's 8% boost applies additively for each additional Spirit Generator skill used, so using two Spirit Generator results in a 16% boost.
I've used a DPS-focused build similar to this that worked reasonably well in Hell. I'm not geared well-enough to run this in Inferno (major survivability issues). Any feedback on the numbers / analysis is much welcome!