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I am trying to understand if there is a logic in health/life globes drops in order to setup a correct strategy in monster killing order. Are they completely random in chance and "size"? Are there monsters (types) that guarantee the drop of a life globe on death or at least that guarantee a certain globe "size" when it drops?

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I'm wondering if this is gonna still drop in inferno –  Michel May 17 '12 at 16:25
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@Michel They have to, otherwise a large swath of builds would be invalidated, and the game would become nearly impossible. –  bwarner May 17 '12 at 17:16
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It seems that there is a logic in health globes drop, at least when dealing with elite enemies (blue, yellow mobs):

  • Blue monsters: 60% chance to drop at 50% and 0% life.
  • Yellow monster: 100% chance at 75%, 50%, 25% and 0% life.

Also, Health Globes dropped from blue and yellow monsters restore 35% of your life (+ boost on equipment) as opposed to 20% from globes dropped by normal monsters.

Normal monsters instead only drop them at death, and the odds depends on the monster.

Source

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From my experience, a health globe is guaranteed if you eliminate:

  • a unique or elite monster (ones with gold or purple above their heads)

  • a group of minions with the blue bar above their heads

This is not including the chance from killing other randoms around the world and this is just speaking from my experience.

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