We hear Zoltan Kulle talk about how he "sacrificed" to make the Black Soulstone; is he referring to something besides his corporeal body? It seems like it could be reminiscent of Fullmetal Alchemist where their magical stone (the Philosopher's Stone) was made via human sacrifice on a large scale.
In keeping with one of D3's themes, the forces that went into constructing it may be partially demonic in origin. This hybrid of demon and angel could create something more powerful than either alone, but the "cost" may have been unpalatable to all but the amoral (viz. Kulle).