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My question is, what is the reasoning behind using twister, is there a large advantage over using something like piercing orb? Is it an AP sink? If so, what is the advantage over using the Arcane Orb that pierces.

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Currently, this sounds like a build question, which we already have. Stats are here. I'd recommend paring the question down to, "When do you prioritize Twister over Piercing Orb?". – fbueckert Aug 31 '12 at 14:29
Will do thanks for the comment =) – dardo Aug 31 '12 at 14:31
I prefer wicked wind myself, but that's just me and I haven't put too much effort into my wizard beyond act 1 inferno – spartacus Aug 31 '12 at 14:45
It's quite a jump, I'm finding personally. Act 1 is facerollingly easy, whereas Act 2 is quite a bit harder. My friend who plays a barb can at least survive decently well with equivalent gear / skill level. – dardo Aug 31 '12 at 14:48
I meant limit the entire question to just that question. :P Asking for build advice invites discussion, which doesn't work so well with the question and answer format of Arqade. Remember, we're here to help, but not play your game for you. They also invite lots of discussion. Hence why I linked the solo wizards build question. – fbueckert Aug 31 '12 at 14:49
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