The first Torchlight had an annoying combat issue that required constant clicking/holding on the enemy you wanted to target. After the enemy was dead, you had to click/hold on a new target.
Torchlight 2 seems to have improved on this a bit. Click/hold on an enemy to attack and kill it just the same. However, while you are holding, you can hover the cursor over a new enemy. When the enemy you are attacking is dead, you will immediately attack the second enemy provided you were able to keep the cursor directly over it.
That's not good enough, though, as I still find myself losing my cursor in the thick of all the action, especially when there are huge mobs. If I could just click and hold and have my character just auto-attack everything in sight until everything is dead, I would like that very much.