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Sometimes when I'm playing, my mouse sensitivity will spontaneously change for no reason. Any thoughts on what can cause this?

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I should note this only happens when I play League, and even then somewhat rarely. Its a bitch when it happens however, as I have to open my league options and re-adjust my sensitivity rather than spend the time farming, killing, ect. – Ender Nov 4 '12 at 17:15
Why the downvote? Downvoting and then not commenting for me to learn from my mistake (if any) is just malicious. – Ender Nov 4 '12 at 19:57
Agreed. I guess someone misunderstood your problem. He must have thought it was a problem caused by windows or even your mouse and not something to do with ingame configuration. Which is obviously not true if you bother to read the comments. – Panagiotis Palladinos Nov 5 '12 at 12:33
You're sure it's the mouse sensitivity settings in league that are changing? It's definitely not windows settings, or accidentally hitting the sensitivity buttons on the mouse (if your mouse has those)? – Ryre Nov 5 '12 at 17:49
@Toast My mouse has no sensitivity setting buttons, the mouse sensitivity does not change in windows settings as if I alt-tab out of League the mouse is the same as it always was. – Ender Nov 5 '12 at 18:42
up vote 3 down vote accepted

This appears to be a known bug that Riot is working to fix (click the Riot logo next to "First Riot Post" in this link):

A few people have reported it fixed as of the last patch, so chime in on that forum post if you're still having trouble after patching! And make sure to submit your logs any game the sensitivity bug occurs.

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