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I am playing Mass Effect again but there doesn't appear to be an option to enable a borderless window mode in either the game or the configuration utility, leaving the game running inside of a visible window.

Is it possible to set a borderless window mode either by editing one of the configuration files or using a third party utility or some kind?

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Mass Effect does not come with any support for borderless window mode. The only way to do so is to use a third party utility such as ShiftWindow.

There are also ways to do it with autohotkey

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this unfortunately doesn't put ME into a borderless window for me, I get a similar effect with another utility that is meant to create borderless windows, I just end up with a window with a border... – kalina Dec 28 '12 at 22:07
@kalina you might be out of luck then, ME is a rather old game – l I Dec 29 '12 at 0:03

Use the following AutoHotKey Script:

WinSet, Style, -0xC00000, a
WinMove, a, , 0, 0, 1680, 1050

When you pree ctrl+alt+a it will make the currently active window borderless.

Replace 1680 and 1050 with the size you want the window to be.

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