Unfortunately, no. The gameplay mechanics aren't compatible with that sort of control scheme, and it's likely impossible to change that kind of fundamental aspect of the game's design and programming.
Even if you could somehow mod the interface to work like that, it wouldn't be playable. The game currently uses the mouse to control the vertical and horizontal angle of your view, which it uses for myriad purposes, chiefly to detect what your attacks are aimed at. If the mouse were co-opted to control movement by clicking where you want to go, you would be unable to attack anything while moving, leaving you easy pickings for enemies. To make such a control scheme work the game's control interface and enemy AI would have to be rewritten from the ground up.