The Binding of Isaac is a randomly generated action RPG shooter with heavy Rogue-like elements.

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43
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2answers
5k views

How can I increase my chances of getting cancer?

In a recent Binding of Isaac playthrough I encountered an item which I had not seen before. It was called "Cancer", and it seemed to increase my DPS considerably. However, since then I have only ...
41
votes
3answers
84k views

Where does the Binding of Isaac store its saved data?

I know you can't save your game in the Binding of Isaac, I am referring to the local save data: unlocks, collection, stats, etc. I move between three computers regularly (home pc, laptop, and work ...
41
votes
5answers
7k views

How can I kill Mom?

Mom keeps haunting my dreams, and after countless battles with this horrible woman, I only find myself badly beaten up. Are there any strategies or items that can make this boss fight somewhat ...
33
votes
1answer
2k views

Why am I peeing?

In Binding of Isaac, I notice that I sometimes leave a little pee puddle upon entering a room. What's causing Isaac to urinate? Is it random or based on an item or effect I have at the moment?
25
votes
3answers
25k views

The Binding of Isaac just got harder, but how?

I have just finished my sixth and seventh full runs of The Binding of Isaac. After completing the sixth run, you do not unlock a new item but instead you just get the "Everything's Terrible!" ...
20
votes
2answers
35k views

Is it possible to save in Binding of Isaac?

I know this is kind of silly but is it possible to save current progress? So far I've been leaving the game running so when I return I can attempt to finish the level but it would be nice to just ...
20
votes
7answers
48k views

How to improve Binding of Isaac performance?

I cannot go past level 3/4 because when I enter in rooms full of monsters the game start lagging a lot and controls do not respond at all or with a huge delay. My configuration is not actually bad: ...
19
votes
5answers
5k views

Which walls are bombable?

I've recently started playing The Binding of Isaac, and I've noticed that some walls can be bombed to reveal a secret room containing coins, or items. The problem is, I can't tell which ones can be ...
18
votes
5answers
83k views

How to setup the joypad for Binding of Isaac?

It seems that Binding of Isaac supports joypad, but simply connecting XBox 360 joypad does not work. Do you know how to setup it?
18
votes
3answers
18k views

How do you open the barred doors in the Binding of Isaac?

These doors are grey and usually (always?) open into a "weapon" room, i.e. there is a weapon on the minimap for them. I've gotten in two, but it was very non-obvious what I did to open the doors. For ...
17
votes
1answer
59k views

What do each of the Tarot cards do?

In The Binding of Isaac, some of the items that you can pick up are special numbered Tarot cards with different special effects when you use them. Some of these trigger events that I don't want to ...
16
votes
4answers
40k views

What am I to do when something appears on one of the levels?

After playing some more the Binding of Isaac I've come across strange messages that are triggered by certain events. For instance, when I defeated one of the bosses, I suddenly got a pop-up message ...
16
votes
2answers
11k views

How can I clear gaps in the Binding of Isaac?

I have coins. I have bombs. I lack keys and health. Obviously means I found a key and a heart pickups; they're so close, and yet so far. Now, I know one of the devil pacts grants you flight. Is ...
16
votes
2answers
3k views

How can I fix my face?

I FOUND SOME PILLS, AND I ATE THEM! ... That's cool and all, but how do I get out of this state? It's not good with the ladies.
15
votes
3answers
3k views

Is the shell game rigged?

When playing the shell game in the Arcade rooms, the shells move pretty fast and I can almost never tell where the prize ends up. I'm not sure if this is attributed to me just having poor focusing ...
15
votes
4answers
6k views

How do I get A Gift from Krampus?

Binding of Isaac has an achievement for "A Gift From Krampus". The hint says it's in Satan's room, but I don't know where that is.
15
votes
2answers
1k views

Can I farm soul hearts from Larry Jr?

I've noticed that the poo piles left by Larry Jr (or the later stage unnamed twin worm-like things) can be broken for hearts and soul hearts. Is there a limit to how many drops can be made from Larry ...
14
votes
2answers
12k views

Do items in Binding of Isaac affect stats that are at max?

In the Binding of Isaac, if a stat has all of its bars filled when I look at the pause screen, does an item that raises that stat for a single room cause an effective increase of that stat past the ...
14
votes
1answer
745 views

What kinds of things can be in poop and are the chances always the same?

So far, I have only found hearts and coins in poop. What else can be in there? Does it depend on where I find the poop? Example: Larry Jr. leaves a lot of poop in his fetid wake. Do these poop ...
13
votes
3answers
16k views

Binding of Isaac achievements and Steam in-game not working

I can't get achievements in this game, also the Steam In-game function doesn't work. May this problem related to the fact that the game is in Flash? Anyone has the same problem?
12
votes
2answers
7k views

Is it wise to try unrecognized pills that I find?

While playing the game "The Binding of Isaac", one occasionly finds pills. I know that the different effects those pills can posses are mentioned here, and that in each game-run there are only 6 ...
11
votes
3answers
779 views

Is there any difference between champion colors?

Do different colored champions have different bonuses, and, if so, what are they? I.e. Are green champions the same as red champions?
11
votes
2answers
2k views

Are there any ways to break rocks without bombs?

Sometimes I have quite a bit of trouble finding bombs or I will need a bomb in order to get more bombs. What ways can I break rocks (via items or enemies) if I have zero actual bombs?
11
votes
2answers
2k views

Can I die if I still have soul hearts?

Can I die if I have soul hearts but lose all my red hearts, either from making a deal with the devil or using the razor or using the blood donation machine?
11
votes
2answers
16k views

What does the lucky foot do?

The wiki states that the lucky foot raises luck. Unfortunately, it fails to state just what that means. So, what does raising my luck do?
11
votes
1answer
22k views

How do I access the Binding of Isaac soundtrack?

I recently bought the Binding of Isaac + soundtrack. ...so how do I actually access the soundtrack? The soundtrack shows up when I view downloadable content via steam, and it shows that I own it in ...
11
votes
1answer
59k views

What are the controls of The Binding of Isaac?

What are all the keys used in The Binding of Isaac? I'm going to configure my joystick using one of the tools suggested at How to setup the joypad for Binding of Isaac? (Xpadder, JoyToKey, QJoyPad, ...
11
votes
2answers
13k views

What are the white hearts?

Apparently multiple items can give you white hearts, like the ones given by Fate. What are these white hearts? What do they do, and what can give them to you?
10
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3answers
1k views

Are there always enough keys on a level?

On a certain level of this basement, I found 2 locked doors but only 1 key. I think I have cleared out everything I can from this level but I still only found one key. Are there always as many keys ...
9
votes
3answers
3k views

How can I unlock Super Bandage?

How can I unlock Super Bandage? It's only item left to unlock Golden God.
9
votes
2answers
2k views

What are all of the rules that determine where secret rooms appear?

The Binding of Isaac with the Wrath of the Lamb expansion has two different secret rooms on each floor. It seems that there are some specific rules that determine where the rooms can appear on the ...
9
votes
5answers
332 views

Is there a method to beating Hosts?

Hosts are the skulls that occasionally raise themselves up to shoot at you. When they raise themselves, that is the only time you can damage them. I can't seem to find any sort of pattern and end up ...
9
votes
1answer
351 views

What is different between the pre-Mom levels and post-Mom levels?

I beat Mom for the first time yesterday and continued into the Womb on a second playthrough. I was doing pretty well (playing Cain, had 6-7 hearts, maxed out tears, high damage, 99 coins and keys, ...
9
votes
1answer
3k views

How do black hearts function?

I just started playing the Binding of Isaac and one of the pick-ups I came across was a black/blue-ish heart (much like the red ones that fill up your HP). Initially, I thought it was a sort of "heart ...
9
votes
1answer
3k views

Is there a limit to how much health I can have?

In The Binding of Isaac, what is the maximum amount of health I can get? Is there even a limit? The health display in the upper-right corner has space for a maximum of 12 hearts. However, during a ...
9
votes
1answer
952 views

Can I skip levels to get the “no damage” achievements?

Several items in the Binding of Isaac allow you to skip a level without facing the boss (We Need to Go Deeper and the Teleport! item, though teleporting is a less reliable form of level skipping). ...
8
votes
1answer
552 views

Why did I turn into a demon instead of dying?

While playing the Binding of Isaac, I should have died when fighting Monstro II, but instead I got a message on a blue screen saying (I think): "Today is a bad day to have a castle". It gave me half a ...
8
votes
2answers
15k views

How do I skip the Intro on Binding of Isaac?

I play the Binding of Isaac, and love the game. Though, I hate the very long intro. Is there anyway to skip it? Please tell me. Thank you.
8
votes
2answers
803 views

When should I use the Blood Donation Machine?

The Blood Donation Machine allows you to trade half a heart pre-Womb or a whole heart in or after the Womb for some amount of money. Additionally, there is a chance that the machine will explode and ...
8
votes
3answers
1k views

What can you get from the Skull Game after Skatole?

After getting Skatole (that's the poop that makes all the flies love you), is it possible to get another useful item if you find a second Skull Game guy on the same playthrough? Or will it be an ...
8
votes
3answers
4k views

How can I find the secret rooms most efficiently?

With the Wrath of the Lamb expansion, The Binding of Isaac now has two different kinds of secret rooms, and together they seem to have somewhat complex placement rules. If I can only search for these ...
8
votes
1answer
822 views

What are the choices presented by this evil statue?

I just found a strange "evil" statue in Binding of Isaac. What are the effects of these offers?
8
votes
1answer
1k views

When and how are Binding of Isaac floors generated?

I guess it's based on random number generator, but when does the engine generate new floors? Just before entering the trapdoor, during the animation or during the cutscene? Or maybe are all floors ...
8
votes
1answer
1k views

Is the Golden God Achievement still possible with wrath of the Lamb?

Can I still get the Golden God! achievement in Wrath of the Lamb or will I only get it when I get the Platinum God! too? The description of both achievements is: "100% of the game" but Golden God! ...
8
votes
1answer
3k views

What's different about red chests?

In the new type of room similar to the challenge room, you are hurt whenever you enter or leave (there are teeth in the doorway). In this room, there was a red chest, and the room was styled similarly ...
8
votes
1answer
478 views

Why did my pills change?

In Binding of Issac Wraith of the Lamb I picked up a Range Down Pill that I already identified. Some time during the play-through it changed to a Range Up Upgrade. I am not sure when it happened or ...
8
votes
1answer
3k views

What happens if I complete the title screen puzzle?

I have beaten Isaac the Cathedral level once, and when I returned to the title screen, there was a rectangle with what appeared to be a piece of a puzzle in it. I infer that I can complete the puzzle ...
7
votes
3answers
929 views

What strategy can I use to beat Isaac?

I'm trying to finally get myself over the Binding of Isaac, and I fear that won't happen until I've beaten the chest level with a few more characters. The problem is that I find it remarkably ...
7
votes
2answers
2k views

Is there an in-game list of my current items' effects?

I have no idea what a lot of these items do. I have seen a small description appear when I first pick up the item, but it goes away after a few seconds. When I pause the game, I can see the list of ...
7
votes
4answers
27k views

How can I play as Judas?

How do I unlock the playable character Judas? As the unlocking requirements are unknown. What exactly are the unlocking requirements?