Typically, only special rooms are marked on the map (item rooms, shops, arcades, bosses, deadly sins, etc.). What's special about the blood room shown below? I tried hurting myself on the spikes, and ...
In the new type of room similar to the challenge room, you are hurt whenever you enter or leave (there are teeth in the doorway). In this room, there was a red chest, and the room was styled similarly ...
Apparently multiple items can give you white hearts, like the ones given by Fate. What are these white hearts? What do they do, and what can give them to you?
I just found a sad/dead blue head (called "Fate" when I picked it up), and now I have half of a white heart (not a soul heart) and wings. What does Fate do?
One of the items the Binding of Isaac expansion Wrath of the Lamb added was the Mitre. When I picked it up I just go the message "You feel blessed" I haven't noticed a change in my shots or anything. ...
I've recently started playing The Binding of Isaac, and I've noticed that some walls can be bombed to reveal a secret room containing coins, or items. The problem is, I can't tell which ones can be ...