The largest and final expansion to The Binding of Isaac. Adds items, bosses, levels, challenges, and more to the base game.

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4
votes
2answers
4k views

What counts as passing on a treasure room?

On the character page, it says I have to "pass on 2 treasure rooms" in order to unlock Samson. If I enter the treasure room, but do not pick up the item, does that count as passing on it?
6
votes
3answers
11k views

Is there anything special about the blood rooms?

Typically, only special rooms are marked on the map (item rooms, shops, arcades, bosses, deadly sins, etc.). What's special about the blood room shown below? I tried hurting myself on the spikes, and ...
8
votes
1answer
3k views

What's different about red chests?

In the new type of room similar to the challenge room, you are hurt whenever you enter or leave (there are teeth in the doorway). In this room, there was a red chest, and the room was styled similarly ...
11
votes
2answers
13k views

What are the white hearts?

Apparently multiple items can give you white hearts, like the ones given by Fate. What are these white hearts? What do they do, and what can give them to you?
5
votes
1answer
3k views

What does Fate do?

I just found a sad/dead blue head (called "Fate" when I picked it up), and now I have half of a white heart (not a soul heart) and wings. What does Fate do?
6
votes
4answers
18k views

What does the Mitre do?

One of the items the Binding of Isaac expansion Wrath of the Lamb added was the Mitre. When I picked it up I just go the message "You feel blessed" I haven't noticed a change in my shots or anything. ...
19
votes
5answers
4k views

Which walls are bombable?

I've recently started playing The Binding of Isaac, and I've noticed that some walls can be bombed to reveal a secret room containing coins, or items. The problem is, I can't tell which ones can be ...