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Coins are still worth picking up because they add to your score. This article over at Mathematical Mischief shows how scores are calculated during a run. The formula is sort of large, but one of the components of a score is coins, which are each worth five points multiplied by your multiplier bonus. Assuming that the calculation on points is correct ...

After unlocks & upgrades, there is no real use for gold (unless you need to purchase characters (which has been completed)). I guess it's just stackable. Edit: The Head Start is a useful one to purchase before each game.