A ton of the mods in FTB are very poorly coded (eg. to check if solar-panels can see sun, they use the dumbest algorithm possible: a for
loop that checks every y-value above it for blocks every freakin' server tick).
To test if this is your issue, remove all world anchors (and all similar blocks that keep chunks loaded) and go far away from your main-base to someplace you've never been (so that everything you've built becomes unloaded). If the "lag" stops, then the problem is most likely a CPU-hungry mod.
There's not much you can do about CPU-hungry mods except turn them offturn them off, or (in single-player only) just promise yourself not to use blocks from the laggy-mods. Because it's a CPU-issue, reducing the graphics won't help. You could try increasing the process priorityincreasing the process priority, but that likely won't help much, and could cause stability problems.
Unfortunately, there's no ultimate-list of laggy mods that I know of, and the list changes with every version anyways. Check the FTB forums Check the FTB forums, and see which mods most server-administrators are currently disabling, and why.