All 3 of the defenses (Block, Dodge, and Parry) are affected by position, though not all on mobs:
Attacks from the rear cannot be parried. Mobs sometimes do so anyways - this can be due to a bug or because they turn very quickly in place.
Players can only dodge attacks if they are facing their opponent, however a mob can dodge attacks that are from behind.
All creatures will now report a Block on attacks from the front, reducing damage caused instead of converting the attack into a "Miss." Creatures will no longer be able to Block attacks from behind.
There may be other effects, this is the only one I could remember off the top of my head, and I don't play a rogue!