With the information commingcoming from the wiki itself, there isare no rewards tofor keeping him alive. However, you can kepekeep him alive through all those mutants (in what I assume is the following segment, I have not played the game myself):
In the Vault Dweller's memoirs, it is disclosed that Dogmeat died in the Mariposa Military Base after running into a force field (although in the game, it is possible to survive the military base with Dogmeat alive - usually by sealing him inside different rooms to protect him from the super mutants).