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All of generation 1 & 2 can be acquired in either HeartGold or SoulSilver. However, with just HeartGold some will be unavailable.

• The 2 Johto and 2 Kanto starters (and their evolutions) that you didn't choose will be unavailable. You need to trade to get the ones you didn't select.
• Vulpix, Ninetales, Meowth, Persian, Kabuto, Kabutops, Ledyba, Ledian, Skarmory, and Delibird are unavailable, as they are SoulSilver exclusives.
• Mew and Celebi are only available from giveaways, so it is unlikely you will be able to catch them.
• Alakazam, Machamp, Golem, Gengar, Politoed, Slowking, Kingdra, Scizor, and Porygon 2 require trading to evolve. Steelix can still be encountered and caught without having to evolve Onix.
• You can get all of Tyrogue and Eevee's evolutions by breeding them with a Ditto, so all 3 himons and all 5 eeveelutions are possible in one game.

This leaves a total of 33 unacquirable Pokémon. You can consider your Pokédex complete at 223.

Source for version exclusive lists: HeartGold/SoulSilver Version Exclusive Pokémon on Bulbapedia

All of generation 1 & 2 can be acquired in either HeartGold or SoulSilver. However, with just HeartGold some will be unavailable.

• The 2 Johto and 2 Kanto starters (and their evolutions) that you didn't choose will be unavailable. You need to trade to get the ones you didn't select.
• Vulpix, Ninetales, Meowth, Persian, Kabuto, Kabutops, Ledyba, Ledian, Skarmory, Tediursa, Ursaring and Delibird are unavailable, as they are SoulSilver exclusives.
• Mew and Celebi are only available from giveaways, so it is unlikely you will be able to catch them.
• Alakazam, Machamp, Golem, Gengar, Politoed, Slowking, Kingdra, Scizor, and Porygon 2 require trading to evolve. Steelix can still be encountered and caught without having to evolve Onix.
• You can get all of Tyrogue and Eevee's evolutions by breeding them with a Ditto, so all 3 hitmons and all 5 eeveelutions are possible in one game.

This leaves a total of 35 unacquirable Pokémon. You can consider your Pokédex complete at 216.

Source for version exclusive lists: HeartGold/SoulSilver Version Exclusive Pokémon on Bulbapedia

All of generation 1 & 2 can be acquired in either HeartGold or SoulSilver. However, with just HeartGold some will be unavailable.

• The 2 Johto and 2 Kanto starters (and their evolutions) that you didn't choose will be unavailable. You need to trade to get the ones you didn't select.
• Vulpix, Ninetales, Meowth, Persian, Kabuto, Kabutops, Ledyba, Ledian, Skarmory, and Delibird are unavailable, as they are SoulSilver exclusives.
• Mew and Celebi are only available from giveaways, so it is unlikely you will be able to catch them.
• Alakazam, Machamp, Golem, Gengar, Politoed, Slowking, Kingdra, Scizor, and Porygon 2 require trading to evolve. Steelix can still be countered and caught without having to evolve Onix.
• You can get all of Tyrogue and Eevee's evolutions by breeding them with a ditto, so all 3 himons and all 5 eeveelutions are possible in one game.

This leaves a total of 33 unacquirable pokemon. You can consider your pokedex complete at 223.

Source for version exclusive lists: https://bulbapedia.bulbagarden.net/wiki/Pok%C3%A9mon_HeartGold_and_SoulSilver_Versions#Game-exclusive_Pok.C3.A9mon

All of generation 1 & 2 can be acquired in either HeartGold or SoulSilver. However, with just HeartGold some will be unavailable.

• The 2 Johto and 2 Kanto starters (and their evolutions) that you didn't choose will be unavailable. You need to trade to get the ones you didn't select.
• Vulpix, Ninetales, Meowth, Persian, Kabuto, Kabutops, Ledyba, Ledian, Skarmory, and Delibird are unavailable, as they are SoulSilver exclusives.
• Mew and Celebi are only available from giveaways, so it is unlikely you will be able to catch them.
• Alakazam, Machamp, Golem, Gengar, Politoed, Slowking, Kingdra, Scizor, and Porygon 2 require trading to evolve. Steelix can still be encountered and caught without having to evolve Onix.
• You can get all of Tyrogue and Eevee's evolutions by breeding them with a Ditto, so all 3 himons and all 5 eeveelutions are possible in one game.

This leaves a total of 33 unacquirable Pokémon. You can consider your Pokédex complete at 223.

Source for version exclusive lists: HeartGold/SoulSilver Version Exclusive Pokémon on Bulbapedia

All of generation 1 & 2 can be acquired in either HeartGold or SoulSilver. However, with just HeartGold some will be unavailable.

• The 2 Johto and 2 Kanto starters (and their evolutions) that you didn't choose will be unavailable. You need to trade to get the ones you didn't select.
• Vulpix, Ninetales, Meowth, Persian, Kabuto, Kabutops, Ledyba, Ledian, Skarmory, and Delibird are unavailable, as they are SoulSilver exclusives.
• Mew & Celebi are only available from giveaways, so it is unlikely you will be able to catch them.
• Alakazam, Machamp, Golem, Gengar, Politoed, Slowking, Kingdra, Scizor, and Porygon 2 require trading to evolve. Steelix can still be countered and caught without having to evolve Onix.
• You can get all of Tyrogue and Eevee's evolutions by breeding them with a ditto.

This leaves a total of 33 unacquirable pokemon. You can consider your pokedex complete at 223.

Source for version exclusive lists: https://bulbapedia.bulbagarden.net/wiki/Pok%C3%A9mon_HeartGold_and_SoulSilver_Versions#Game-exclusive_Pok.C3.A9mon

All of generation 1 & 2 can be acquired in either HeartGold or SoulSilver. However, with just HeartGold some will be unavailable.

• The 2 Johto and 2 Kanto starters (and their evolutions) that you didn't choose will be unavailable. You need to trade to get the ones you didn't select.
• Vulpix, Ninetales, Meowth, Persian, Kabuto, Kabutops, Ledyba, Ledian, Skarmory, and Delibird are unavailable, as they are SoulSilver exclusives.
• Mew and Celebi are only available from giveaways, so it is unlikely you will be able to catch them.
• Alakazam, Machamp, Golem, Gengar, Politoed, Slowking, Kingdra, Scizor, and Porygon 2 require trading to evolve. Steelix can still be countered and caught without having to evolve Onix.
• You can get all of Tyrogue and Eevee's evolutions by breeding them with a ditto, so all 3 himons and all 5 eeveelutions are possible in one game.

This leaves a total of 33 unacquirable pokemon. You can consider your pokedex complete at 223.

Source for version exclusive lists: https://bulbapedia.bulbagarden.net/wiki/Pok%C3%A9mon_HeartGold_and_SoulSilver_Versions#Game-exclusive_Pok.C3.A9mon