This information is so hard to come by so I'm posting here in response. The first quest comes very early in the game. I rejected itthe quest, and it never came back even after my whole squad is on end game armor.
Started another game, and this time I accepted and finished the first mission. And then for the 2nd and 3rd quest, these comescome ridiculously early as well and you probably won't beat it with your newbie squad with stick weapons, so skip them and do it later. The council SPAMS you with it andthe quest, but there's no penalty whatsoever for not completing itthe quest when it shows up.
In short, don'tdon't skip the first mission, the following ones can be skippedthe following ones can be skipped.