I've found that a lot of this game involves simply waiting for money to roll in. It would be really nice to be able to build a city up to a point where it is 'stable', and then simply let the city run in the background accumulating wealth while I do other more productive and interesting tasks instead of just staring at my bank account increasing while occasionally dealing with the every now-and-then disaster. Even more importantly, before I learned the importance of education, my first nuclear power center had a meltdown rendering basically half of my city uninhabitable. Evidently, the radiation is supposed to eventually disappear, but only after some 20 or so odd in-game years, something I really don't want to have to actually wait through.
Unfortunately, I've found that even in windowed mode, as soon as the window loses focus, the game seems to pause itself. Has anybody found a way to alter this behavior so as to allow the game to run in the background?