I tested out that the MULES of Terran do not "colide" with SCVs. One mineral patch can have 2 SCVs working at the same time. If the distance is long enough the SCVs work perfectly in groups of 3-4 (2 collect and the others travel). With MULES one mineral patch can have 1 MULE and 2 SCVs without interrupting each other. The rule is that 2 MULES can't work at the same time on a mineral patch.
The problem is that if you drop all your MULES always on the same mineral patch, it gets drained way faster than the others and therefore 2-4 SCVs lose their job in that base and become obsolete.
My question is how to minimize that effect considering that a usual base in Starcraft II has 4 mineral patches with double the amount of the other 4. Those with half the amount are further away to compensate. Every other race mines them out evenly if they send exactly 16 workers on those 8 mineral patches.