In Mass Effect 3 you can choose to play campaign in Story, Action or RPG mode.
I know the difference between them is that Story focuses on plot while ignoring FPS elements; Action removes dialogue options and is focused on FPS elements; and RPG focuses on both plot and action aspects of the game.
My question would be - beyond things I mentioned above, is the game customized in any other way (by selecting one of them and not others)? Is there any possible ending "locked" in a certain mode?