The problem with open world sandbox games is that the more you win, the more boring the world gets. (I think I'm the only person in the world that really enjoyed Far Cry 2's respawning outposts).
The first time I played InFamous, I did every side mission. By the end of it, I had all these totally super sweet powers...and nobody to use them on! Saints Row, same thing! By the time you get the cool guns, you've cleared half the map and there's nobody to do drive-by RPG'ings at.
I told myself this wouldn't happen with Far Cry 3. As soon as I figured out that clearing outposts prevented enemies from spawning, I stopped doing it. Here's a quick graphic of my progress so far:
And it's working! When I travel from mission to mission, I actually have to be on my guard! Random encounters happen! I get to continuously murder people with bullets. I am 100% ok with this.
But...whenever I run out of murdering ammo, I have to trek halfway across the continent to find a friendly gun store. And God forbid I die...respawning sets me so far back from my goal it's like I'm playing EVE Online. I just feel like I've traded one drudge for another. Also, I'm worried that there might be in-game rewards (such as the radio towers = free guns) for clearing outposts that I'm not getting.
Am I missing out on anything important by not clearing outposts and radio towers?