Are there differences in terms of quests, changes of the gameplay?
I know some NPCs were added, but is there something that has been removed?
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The new companions correspond to some of the new class choices that are available. The Blackguard kit for Paladin, the Monk (base class, but implemented interally as a Thief variant), and Wild Mage kit for the Wizard. There are also the Sorceror and Barbarian classes, and a few other kits that BG1 didn't have.
There are some changes to the user-interface to scale it to larger resolutions, and mouse-wheel or pinch can zoom in or out the scaling.
Some changes that will also be evident from comparing Baldur's Gate 2 to Baldur's Gate, because they are doing the same as the Tutu mods and running a fixed-up version of the Baldur's Gate 2 version of the Infinity Engine to run the original game: two items of note here, aside from the above
I believe the team wanted to implement more new races but weren't allowed to by Atari or Wizards (not sure whom), but you get Half-Orc addition at least.
Various mods out there fixed issues with the original game. A short list from this forum post explains which ones are no longer needed:
Edit: I just realized there's one actual removal-- there is no longer EAX support for position audio and reverb. It's a little disappointing but not a deal-breaker, IMO.