If you're able to kill everyone without being seen (red bolt above their head) will you still get ghost?
Goes by the joke, "You can't get detected if there's no one to detect."
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Sign up to join this communityAs far as the 'Mission Stats' checkbox is concerned - yes, it is possible. Here is proof from a stealthy, super-lethal playthrough of mine of the 'House of Pleasure' mission (with no Shadow Kill). In the screenshot of the mission stats below, notice that there are 44 hostiles killed, 'Didn't Kill Anyone' is not checked, but 'Ghost (Never Detected)' is checked:
Basically, as long as no red 'marker' appears on an NPC or a wolfhound (dog), it won't count as detected. Three white 'markers' won't count as detected.
(Parts of this post are copied from an answer of mine in the question, Do “Bodies Found” Count Against Ghosting?)
If they are not aware of you, before you attack them, it counts as a stealth kill and ghost will still be awarded. Most players tend to stack the no kill achievements with Ghost though.
This also applies to sleeping darts and other non lethal and lethal take downs. Obviously pistols are ruled out since they make others detect you.
Killing will invalidate the achievement:
Complete all missions after the prologue, alerting or killing no one but the key targets
You can, however, knock them all unconscious to the same effect. You can't get detected if there's no one awake to detect you.
Killing will not invalidate the end of mission checkbox:
All characters and creatures count as detecting the player character, with the exception of friendly characters, Rats, River Krust, Hagfish and Watchtowers. This is evidenced by the red bolt icons upon detection.
Friendly characters will turn into a detection if they see your character do anything aggressive/hostile (kill someone, be hostile towards the NPC, carry a dead/subdued body, etc.). They will gain the red bolts when this happens.
So all you really need to do for this is go undetected and get no red bolts.