I'm prepping my lawful human valk for the midgame, just unloaded a bunch of extra items to my stash in Sokoban, completed Mine's End, and ID'ed a bunch of scrolls, potions, etc, without any negative effects that I noticed.
Now, however, I've started going deeper into the dungeon, and I can't seem to find any hidden doors any more, and I know that some should be there (for instance, I found a 'Vlad was Here' tile and there has to be a door). I have Excalibur, a luckstone, and can't for the life of me figure out why my searching is now rendered useless...is there anything that could cause this?