Just finished playing the Allied campaign, and the mastermind tanks are a massive pain. I tried to blow them up from a distance with prism tanks, but their armor is very heavy.
One major weakness with this weapon system however, is its lack of self-defensive armament. This makes it completely helpless against units immune to psychic control such as Terror drones, robot tanks and air units when airborne. As mentioned above however, it's greatest weakness is that this weapons system is prone to burning out when it has too many units under its control. This led to the tactic of rushing the Mastermind with many cheap and fast units such as Conscripts, Flak Tracks or IFVs. Paratrooper conscripts are ideal for this task as they are both free and plentiful. Yuri's Masterminds can control up to 3 units each without going into overdrive.
- Rush with cheap units to achieve self destruct.
- Use flyers or robots (terror drone, robot tank) as immune to control