I have the PopCap Hits 2 collection on Xbox 360, but the Xbox sounds like a vacuum cleaner reading that very disc (it's silent with all my other games). I play Plants vs Zombies a lot, and I'm thinking of buying it from the arcade store just so I can play it without the disc. I won't bother if it can't read my current save files though.
Additional info: The Xbox appears to treat the games on the compilation disc as individual arcade games - When I insert the disc each of the games pops up as a separate arcade game in the game list.