So, I killed the old lady in the orphanage pretty early like level 2, now, I'm a level 20 and Constance Michel is still frantic and running around. How do I get her to calm down? It's getting pretty upsetting. :/
From the elder scroll wiki :
Whether she saw the murder of Grelod or not, Constance will remain in a state of panic from Grelod's death until Innocence Lost is completed by talking to Aventus Aretino. However, she will not acknowledge the Dragonborn as the murderer once this questline is completed.