In an attempt to go for the million dollar achievement, while it hurts to sit from how hard this game has been violating me, the most painful part is that it never gives me a moment's silence. The characters, especially GlaDOS, are constantly chattering and interrupting, preventing me from actually playing the game. The dialogue was entertaining once upon a time, but has grown increasingly repetitive. I recall from farming hands in the first Poker Night that right clicking the mouse would skip dialogue and that there was also an option to reduce the frequency of the chatting, but I am finding that neither of these seem to be available this time around. Does there exist some way that I'm not finding to skip the talking so I can actually play the game?
I feel your pain. It seems like the conversations in Poker Night 2 are not only more frequent, but far more repetitive than in the original; adding an additional character (GlaDOS) to the mix only increases the chatter.
Also, there's another unfortunate change that was made from Poker Night at the Inventory to Poker Night 2; there is no dialogue skipping during play or conversation frequency setting in the options menu. The best you can manage, sadly, is just muting the game.
Disclaimer: I uninstalled this game a short while back, so it's entirely possibly, though unlikely, that they've patched the option in. I did some searching and people are still having the same complaint everywhere, leading me to believe this is still an issue.