I got Dire AIDS from battling 'Dire' wildlife in Canada.
Suppose I didn't have it cured, are there any negative gameplay effects if I have it?
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Dire AIDS inflicts a combat debuff on your player that causes minor health damage each turn.
Unlike other debuffs, Dire AIDS has no duration, persists in between combats, and is not curable through consumable items. The only way to get rid of it is to visit the hospital in Canada.
Dire AIDS does have some benefit. If you complete the final battle while inflicted, you get rewarded with an achievement.